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EXPAREL is available in two doses: 266 mg (20 mL) and 133 mg (10 mL). To ensure optimal analgesic coverage, the volume should be expanded for larger surgical sites. To attain early analgesic onset, bupivacaine HCl can be administered immediately before EXPAREL or admixed in the same syringe as part of the total expanded volume.
Adults
Recommended Dose
Maximum dose of 266 mg (20 mL)Based on
Pediatric patients
(aged 6 to less than 17 years)
Recommended Dose
4 mg/kg (up to a maximum of 266 mg)Based on
WeightInterscalene brachial plexus nerve block in adults
Recommended Dose
133 mg (10 mL)Based on
Study of patients undergoing rotator cuff repair or total shoulder arthroplastyAdductor canal block in adults
Recommended Dose
133 mg (10 mL) admixed with 50 mg (10 mL) 0.5% bupivacaine HCl, for a total volume of 20 mLBased on
Study of patients undergoing total knee arthroplastySciatic nerve block in the popliteal fossa in adults
Recommended Dose
133 mg (10 mL)Based on
Study of patients undergoing bunionectomy
The 266 mg (20mL) dose is
appropriate for*
Abdominal/colorectal/general/urologic: abdominal wall reconstruction, bariatric, colectomy, hernia, nephrectomy
Breast: mastectomy, breast reconstruction
OB/GYN: C-section, hysterectomy, myomectomy
Orthopedic: fusions/fractures, THA, TKA
Spinal: discectomy, fusions, laminectomy
Fascial plane blocks: ESP, PECS I and II, QL, rectus sheath, TAP
The 133 mg (10 mL) dose is appropriate for small anatomical areas, such as*
Facial/plastic
Oral/maxillofacial
Upper extremity: interscalene brachial
plexus nerve block
Lower extremity: adductor canal block or sciatic nerve block in the popliteal fossa
C-section, cesarean section; ESP, erector spinae plane; OB/GYN, obstetrics/gynecology; PECS, pectoralis; QL, quadratus lumborum; RCR, rotator cuff repair; TAP, transversus abdominis plane; THA, total hip arthroplasty; TKA, total knee arthroplasty;
*These are examples of procedures that typically require the above-referenced dose of EXPAREL. Please use your professional clinical judgment when determining the appropriate dose of EXPAREL for a given surgical procedure and refer to the full Prescribing Information before using.
*Bupivacaine HCl is indicated for use in patients aged 12 years and older.
*Bupivacaine HCl is indicated for use in patients aged 12 years and older.
ASP, average sales price; CMS, Centers for Medicare and Medicaid Services.
EXPAREL® (bupivacaine liposome injectable suspension) is indicated to produce postsurgical local analgesia via infiltration in patients aged 6 years and older and regional analgesia in adults via an interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and an adductor canal block. Safety and efficacy have not been established in other nerve blocks.
Please refer to full Prescribing Information.
EXPAREL® (bupivacaine liposome injectable suspension) is indicated to produce postsurgical local analgesia via infiltration
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