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What makes EXPAREL unique?

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EXPAREL is a long lasting non-opioid option for post-surgical pain control

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EXPAREL is designed to deliver controlled levels of bupivocaine and utilizes

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proprietary multivesicular liposome, pMVL technology

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an advanced drug delivery platform to extend analgesia.

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EXPAREL encapsulates bupivocaine in multivesicular liposomes that are composed

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of naturally occurring biocompatible lipids.

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As the lipids gradually break down,

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the bupivacaine is safely and consistently released throughout the surgical

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site, EXPAREL releases bupivacaine over time.

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Only a small amount of bupivacaine is released following injection of EXPAREL.

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The majority is released from the multivesicular liposomes over a period of days.

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To attain early analgesic onset, Bupivacaine HCL can be

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administered immediately before or admixed with EXPAREL as part of

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the total volume.

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Admixing may impact the pharmacokinetic and or pharmacodynamic properties

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and the effect is concentration dependent. To cover large surgical sites,

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EXPAREL may be expanded with normal saline or lactated ringer solution.

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Maintain a minimum concentration of 0.89 milligrams per milliliter.

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EXPAREL is a suspension, and unlike traditional bupivocaine,

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it does not readily diffuse.

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The number of multivesicular liposomes present in a surgical site

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impacts the local bupivacaine concentration and therefore the efficacy

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and duration. Ensure enough multivesicular liposomes

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are available at the pain receptors to continuously release bupivacaine for long

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lasting analgesia. To determine the right volume,

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consider the size vascularity and neuroanatomy of the surgical site.

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EXPAREL achieves targeted analgesia.

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The multivesicular liposomes in EXPAREL stay precisely where placed,

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therefore, EXPAREL requires more injections.

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To ensure adequate pain receptor coverage,

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use a 25 gauge or larger bore needle to maintain the structural

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integrity of the liposomes. Infiltrate

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using a frequent and consistent injection technique to distribute

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EXPAREL throughout the surgical site. Inject frequently in small areas,

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one to one and a half centimeters apart.

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Using a moving needle technique, slowly and deeply,

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inject one to two milliliters of EXPAREL into soft tissues.

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Infiltrate above and below the fascia and into the subcutaneous tissue.

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To ensure complete analgesic coverage, aspirate frequently to

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minimize risk of intravascular injection.

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The volume administered and the administration technique are critical to

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achieving optimal results.

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EXPAREL provides long lasting post-surgical pain control while reducing

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or eliminating the need for opioids.